A growing demand for fuel is likely to lead to the development of genetically modified (GM) crops that can be used as commodities for agrofuels. Market pressure could lead to an acceptance of lower regulatory standards for their risk assessment and conditions for cultivation. Contamination of food and feed crops with non-edible GM agrofuel crops can threaten food safety and food security. Simulations therefore must not only focus on percentages of GM contamination, but have to take other aspect of cultivating non-food/feed GM crops into account.